The Periodontal Tissue Health Status of Patients with Chronic Kidney Disease
https://doi.org/10.53770/medica.v8i5.901
Keywords
Chronic Kidney Disease Community Periodontal Index of Treatment Needs Gingival Index Periodontal HealthAbstract
Chronic Kidney Disease (CKD) is a significant global health issue, affecting approximately 700 million people worldwide. This study investigates the periodontal health of CKD patients in Banyumanik District, Semarang, Central Java, Indonesia, where the prevalence of CKD is notably high. A cross-sectional analysis involving 44 CKD patients from three community health centers was conducted. Data were collected through medical records and periodontal examinations using the Community Periodontal Index of Treatment Needs (CPITN) and the Gingival Index (GI). Results indicated that 70% of participants exhibited moderate to severe gingival inflammation, with an average GI score of 1.75. The majority required phase I periodontal treatment, including scaling and root planning. Significant correlations were found between gingival inflammation and factors such as hemodialysis history and the duration of CKD. Patients undergoing hemodialysis showed higher levels of gingival inflammation compared to those who were not. The findings highlight the critical need for regular periodontal assessments and interventions in CKD patients to mitigate oral health complications and improve overall quality of life. This study underscores the importance of integrating oral health management into the care of CKD patients, particularly in regions with high prevalence rates.
Downloads
References
Adibelli, Z., & Duran, C. (2021). The compatibility of the treatment modalities to the recommendations of the kidney disease outcomes quality initiative guideline in chronic kidney disease patients with diabetes. Iranian Journal of Public Health, 50(6), 1206–1212. https://doi.org/10.18502/ijph.v50i6.6419
Burnier, M., & Damianaki, A. (2023). Hypertension as Cardiovascular Risk Factor in Chronic Kidney Disease. Circulation Research, 132(8), 1050–1063. https://doi.org/10.1161/CIRCRESAHA.122.321762
Carrero, J. J., Grams, M. E., Sang, Y., Ärnlöv, J., Gasparini, A., Matsushita, K., ... & Coresh, J. (2017). Albuminuria changes are associated with subsequent risk of end-stage renal disease and mortality. Kidney international, 91(1), 244-251. https://doi.org/10.1016/j.kint.2016.09.037
Chaudhry, A., Kassim, N. K., Zainuddin, S. L. A., Taib, H., Ibrahim, H. A., Ahmad, B., Hanafi, M. H., & Adnan, A. S. (2022). Potential Effects of Non-Surgical Periodontal Therapy on Periodontal Parameters, Inflammatory Markers, and Kidney Function Indicators in Chronic Kidney Disease Patients with Chronic Periodontitis. Biomedicines, 10(11), 1–11. https://doi.org/10.3390/biomedicines10112752
Dinas Kesehatan Kota Semarang. (2021). Profil Kesehatan Kota Semarang 2021 [2021 Health Profile of Semarang City]. Semarang: Dinas Kesehatan Kota Semarang. Retrieved from https://dinkes.semarangkota.go.id/asset/upload/Profil/Profil%202021/FIX_Profil%20Kesehatan%202021.pdf
Francis, A., Harhay, M. N., Ong, A. C. M., Tummalapalli, S. L., Ortiz, A., Fogo, A. B., Fliser, D., Roy-Chaudhury, P., Fontana, M., Nangaku, M., Wanner, C., Malik, C., Hradsky, A., Adu, D., Bavanandan, S., Cusumano, A., Sola, L., Ulasi, I., & Jha, V. (2024). Chronic kidney disease and the global public health agenda: an international consensus. Nature Reviews Nephrology, 20(7), 473–485. https://doi.org/10.1038/s41581-024-00820-6
Garneata, L., Slusanschi, O., Preoteasa, E., Corbu-Stancu, A., & Mircescu, G. (2015). Periodontal Status, Inflammation, and Malnutrition in Hemodialysis Patients - Is There a Link? Journal of Renal Nutrition, 25(1), 67–74. https://doi.org/10.1053/j.jrn.2014.07.004
Hamza, E., Metzinger, L., & Meuth, V. M. Le. (2020). Uremic toxins affect erythropoiesis during the course of chronic kidney disease: A review. Cells, 9(9), 1–18. https://doi.org/10.3390/cells9092039
Kaupke, C. J., Zhang, J., Cesario, T., Yousefi, S., Akeel, N., & Vaziri, N. D. (1996). Effect of hemodialysis on leukocyte adhesion receptor expression. American Journal of Kidney Diseases, 27(2), 244–252. https://doi.org/10.1016/S0272-6386(96)90548-X
Kementerian Kesehatan Republik Indonesia. (2018). Laporan Nasional RISKESDAS 2018 [2018 RISKESDAS National Report]. Jakarta: Kementerian Kesehatan Republik Indonesia.
Kementerian Kesehatan Republik Indonesia. (2023). Survei Kesehatan Indonesia (SKI) [Indonesian Health Survey (SKI)]. Jakarta: Kementerian Kesehatan Republik Indonesia.
KKönigsbrügge, O., Meisel, H., Beyer, A., Schmaldienst, S., Klauser‐Braun, R., Lorenz, M., ... & Ay, C. (2021). Anticoagulation use and the risk of stroke and major bleeding in patients on hemodialysis: From the VIVALDI, a population‐based prospective cohort study. Journal of Thrombosis and Haemostasis, 19(12), 2984-2996. https://doi.org/10.1111/jth.15508
Krishnan, N., Vijay Kumar, S., Nair, A., Kavitha, R., Govind, M., & Remya, M. (2023). Oral health status of individuals affected with chronic kidney disease: A cross-sectional study. Journal of Head and Neck Physicians and Surgeons, 11(1), 39–43. https://doi.org/10.4103/jhnps.jhnps_98_22
Laky, M., Anscheringer, I., Wolschner, L., Heber, S., Haririan, H., Rausch-Fan, X., Volf, I., Moritz, A., & Assinger, A. (2020). Periodontal treatment does not result in detectable platelet activation in vivo. Clinical Oral Investigations, 24(5), 1853–1859. https://doi.org/10.1007/s00784-019-03049-x
Liakopoulos, V., Jeron, A., Shah, A., Bruder, D., Mertens, P. R., & Gorny, X. (2018). Hemodialysis-related changes in phenotypical features of monocytes. Scientific Reports, 8(1), 1–12. https://doi.org/10.1038/s41598-018-31889-2
Lim, K. A., & Lee, J. H. (2022). Factors Affecting Quality of Life in Patients Receiving Hemodialysis. Iranian J Publ Health, 51(2), 355–363. https://doi.org/10.1097/NCC.0000000000000990
Menezes, C. R. S. D., Pereira, A. L. A., Ribeiro, C. C. C., Chaves, C. O., Guerra, R. N. M., Thomaz, É. B. A. F., Monteiro-Neto, V., & Alves, C. M. C. (2019). Is There Association between Chronic Kidney Disease and Dental Caries? A Case-Controlled Study. Medicina Oral Patologia Oral y Cirugia Bucal, 24(2), e211–e216. https://doi.org/10.4317/medoral.22737
Nathalya Dwi, K. S., Notopuro, P. B., Hernaningsih, Y., & Widodo. (2020). Hemoglobin, Hematocrit, Leukocyte, and Platelet Changes Due To Ultrafiltrationhemodialysis in Chronic Kidney Disease Patients. Indonesian Journal of Clinical Pathology and Medical Laboratory, 26(3), 340–343. https://doi.org/10.24293/ijcpml.v26i3.1565
Nitta, K., Okada, K., Yanai, M., & Takahashi, S. (2014). Aging and chronic kidney disease. Kidney and Blood Pressure Research, 38(1), 109–120. https://doi.org/10.1159/000355760
Owlia, P., Salari, M., Saderi, H., & Kadkkoda, Z. (2000). Study of Relationship Between Depth Of Periodontal Pockets, Anaerobic Bacteria and Inflammatory Cells in Periodontitis. Iranian J Publ Health, 29(1), 72–76.
Palmeira, E., Egido-Moreno, S., Omaña-Cepeda, C., Segura-Egea, J. J., & Lopez-Lopez, J. (2024). Oral manifestations in different stages of chronic kidney disease. J Clin Med Img, 7(21), 1-13.
Parsegian, K., Randall, D., Curtis, M., & Ioannidou, E. (2022). Association between periodontitis and chronic kidney disease. Periodontology 2000, 89(1), 114–124. https://doi.org/10.1111/prd.12431
Raeesi, V., Mohammadi Moghaddam, M., Naghavi, A., & Mozafari, G. (2023). The effect of scaling and root planning on the periodontal condition in hemodialysis patients: A clinical trial study. Health Science Reports, 6(8). https://doi.org/10.1002/hsr2.1520
Ruokonen, H., Nylund, K., Meurman, J. H., Heikkinen, A. M., Furuholm, J., Sorsa, T., Roine, R., & Ortiz, F. (2019). Oral symptoms and oral health-related quality of life in patients with chronic kidney disease from predialysis to posttransplantation. Clinical Oral Investigations, 23(5), 2207–2213. https://doi.org/10.1007/s00784-018-2647-z
Tawfig, A., Jamal, B., Eskandrani, R., AlDayel, L., AlTwaijry, S., AlGhamdi, E., & Ahmed, B. (2016). Assessment of Periodontal Disease Severity among Patients at Different Stages of Chronic Kidney Disease. Journal of International Oral Health, 8(3), 307–312. https://doi.org/10.2047/jioh-08-03-02
Vladu, I. M., Cojan, T. S. T., Demetrian, A., Cristea, O. M., Ene, C. G., & Clenciu, D. (2019). The presence of chronic kidney disease in relation to age and duration of diabetes mellitus. Revista de Chimie, 70(4), 1471–1475. https://doi.org/10.37358/rc.19.4.7151
Wirnsberger, G. (2018). Kidney Disease in Old Age. In Learning Geriatric Medicine: A Study Guide for Medical Students (pp. 151-159). Cham: Springer International Publishing. https://doi.org/10.1007/978-3-319-61997-2_16
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 MEDICA (International Medical Scientific Journal)

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.




