Effectiveness of Loranthus sp. Liquid Soap in Improving Skin Moisture among Pregnant Women with Gestational Diabetes Mellitus

https://doi.org/10.53770/medica.v8i8.1266

Authors

  • Siti Choirul Dwi Astuti Poltekkes Kemenkes Gorontalo, Gorontalo, Gorontalo, Indonesia
  • Nancy Oiii Poltekkes Kemenkes Gorontalo, Gorontalo, Gorontalo, Indonesia
  • Hasnawatty Surya Porouw Poltekkes Kemenkes Gorontalo, Gorontalo, Gorontalo, Indonesia
  • Dicki Bakhtiar Purkon Poltekkes Kemenkes Bandung, Bandung, Bandung, Indonesia
  • Ayu Nala El Muna Haerussana Poltekkes Kemenkes Bandung, Bandung, Bandung, Indonesia

Keywords

Diabetes Mellitus Loranthus sp. Liquid Soap Pregnancy Skin Moisture

Abstract

Gestational diabetes mellitus frequently causes skin dryness due to impaired microcirculation, peripheral neuropathy, and reduced sweat gland function, increasing the risk of skin infection and decreasing maternal quality of life. Natural topical products containing bioactive compounds may provide a safe alternative for improving skin hydration during pregnancy. This study aimed to determine the most effective concentration of Loranthus sp. liquid soap for improving skin moisture in pregnant women with gestational diabetes mellitus. A quasi-experimental study using a nonequivalent control group design was conducted at the Tilango Community Health Center, Gorontalo Regency, Indonesia. Thirty pregnant women with gestational diabetes mellitus were allocated into three intervention groups receiving Loranthus sp. liquid soap containing 5%, 10%, or 15% extract (n=10 per group). Participants used 500 mL of the assigned soap twice daily for seven consecutive days. Skin moisture was measured before and after the intervention using digital skin moisture analyzer EH900U. Within-group differences were analyzed using the Wilcoxon signed-rank test, while differences among intervention groups were assessed at a significance level of 0.05. Mean skin moisture increased from 34.6±3.1% to 37.1±5.1% in the 5% group, from 34.8±4.8% to 37.9±4.9% in the 10% group, and from 37.0±5.3% to 45.6±4.3% in the 15% group. Significant improvements were observed in all groups (p=0.041, p=0.026, and p=0.0001, respectively), with a significant difference among concentrations (p=0.0017). The 15% Loranthus sp. liquid soap demonstrated the greatest improvement in skin moisture and showed potential to improve skin moisture in pregnant women with gestational diabetes mellitus. Further studies with larger sample sizes, longer follow-up periods, and an appropriate control group are needed to confirm these findings.

Downloads

Download data is not yet available.

References

Abera, B. H., Diro, A., & Beyene, T. T. (2023). The synergistic effect of waste cooking oil and endod (Phytolacca dodecandra) on the production of high-grade laundry soap. Heliyon, 9(6), e16889. https://doi.org/10.1016/j.heliyon.2023.e16889

Adjei, F., Amponsah, E., Ebo-Donkor, P., Smith, J. B., & Tulashie, S. K. (2022). Formulation of mosquito repellent soap using neem extract, and Musa paradisiaca covers as a substitute source of alkalis. Case Studies in Chemical and Environmental Engineering, 5, 100171. https://doi.org/10.1016/j.cscee.2021.100171

Azme, S. N. K., Yusoff, N. S. I. M., Chin, L. Y., Mohd, Y., Hamid, R. D., Jalil, M. N., Zaki, H. M., Saleh, S. H., Ahmat, N., Manan, M. A. F. A., Yury, N., Hum, N. N. F., Latif, F. A., & Zain, Z. M. (2023). Recycling waste cooking oil into soap: Knowledge transfer through community service learning. Cleaner Waste Systems, 4, 100084. https://doi.org/10.1016/j.clwas.2023.100084

Bradley, C. L., Wieder, K., & Schwartz, S. E. (2021). Pass the SOAP: Shifting from SOAP to consult notes for clinical documentation in pharmacy students. American Journal of Pharmaceutical Education, 85(9), 8781. https://doi.org/10.5688/ajpe8781

Byrka, K., & Kaminska, K. (2022). Doing laundry with biodegradable soap nuts: can rare and novel behaviors break bad habitual patterns? Journal of Environmental Psychology, 79, 101730. https://doi.org/10.1016/j.jenvp.2021.101730

Chirani, M. R., Kowsari, E., Teymourian, T., & Ramakrishna, S. (2021). Environmental impact of increased soap consumption during COVID-19 pandemic: Biodegradable soap production and sustainable packaging. Science of the Total Environment, 796, 149013. https://doi.org/10.1016/j.scitotenv.2021.149013

Eumelen, G. J. A. M., Bosco, E., Suiker, A. S. J., & Hermans, J. J. (2023). Chemo-mechanical model for degradation of oil paintings by amorphous and crystalline metal soaps. European Journal of Mechanics, A/Solids, 97, 104827. https://doi.org/10.1016/j.euromechsol.2022.104827

Falciani, G., Bergamasco, L., Amati, A., Verdoes, G., Sen, I., Bonnet, S., & Chiavazzo, E. (2023). Design and testing of a device for the characterization of gas transfer through soap films and measurement protocol based on color matching. International Communications in Heat and Mass Transfer, 149, 107161. https://doi.org/10.1016/j.icheatmasstransfer.2023.107161

Fatchiyah, F., Rahmania Criswahyudianti, E., Kurnianingsih, N., Pristi Yunita, E., & Putri Virgirinia, R. (2023). Antimicrobial activity and stability evaluation of soap from caprine milk, yogurt, and kefir. Journal of King Saud University - Science, 35(8), 102908. https://doi.org/10.1016/j.jksus.2023.102908

Gao, C. J., & Kannan, K. (2020). Phthalates, bisphenols, parabens, and triclocarban in feminine hygiene products from the United States and their implications for human exposure. Environment International, 136, 105465. https://doi.org/10.1016/j.envint.2020.105465

Kolonnage, T. N., & Chew, I. M. L. (2023). Environmental and cost analysis for polyhydroxyalkanoate production from glycerol byproduct: A case study from integrated soap and biodiesel plants. Cleaner Environmental Systems, 9, 100123. https://doi.org/10.1016/j.cesys.2023.100123

Leistner, R., Kohlmorgen, B., Brodzinski, A., Schwab, F., Lemke, E., Zakonsky, G., & Gastmeier, P. (2023). Environmental cleaning to prevent hospital-acquired infections on non-intensive care units: a pragmatic, single-centre, cluster randomized controlled, crossover trial comparing soap-based, disinfection and probiotic cleaning. EClinicalMedicine, 59, 101958. https://doi.org/10.1016/j.eclinm.2023.101958

Lolok, N., Awaliyah, N., & Astuti, W. (2020). Formulasi dan uji aktivitas sediaan sabun cair pembersih kewanitaan ekstrak daun waru (Hibiscus tiliaceus) terhadap Jamur Candida albicans. Jurnal Mandala Pharmacon Indonesia, 6(1), 59–80. https://doi.org/10.35311/jmpi.v6i01.53

Mussagy, C. U., Farias, F. O., Santos-Ebinuma, V. C., Pereira, J. F. B., & Pessoa, A. (2023). Sustainable one-pot platform for the green recovery of carotenoids from Phaffia rhodozyma yeast and their use as natural additives in soap formulation. Environmental Technology and Innovation, 29, 103029. https://doi.org/10.1016/j.eti.2023.103029

Mzimba, N. F., Moteetee, A., & van Vuuren, S. (2023). Southern African plants used as soap substitutes; phytochemical, antimicrobial, toxicity and formulation potential. South African Journal of Botany, 163, 673–683. https://doi.org/10.1016/j.sajb.2023.11.002

Oyekunle, J. A. O., Ore, O. T., Ogunjumelo, O. H., & Akanni, M. S. (2021). Comparative chemical analysis of Indigenous Nigerian soaps with conventional ones. Heliyon, 7(4), e06689. https://doi.org/10.1016/j.heliyon.2021.e06689

Pandey, J., Gaire, S., Sharma, K., Pun, D., Gyawali, A., Lamichhane, G., Budean, D., & Devkota, H. P. (2023). Exploring the potentials of Ziziphus mauritiana Lam. seed kernel oil as pharmaceutical oil base: physicochemical characterization and ketoconazole soap formulation. Heliyon, 9(11), e21034. https://doi.org/10.1016/j.heliyon.2023.e21034

Puspawiningtiyas, E., Pratiwi, M., Purwadi, R., Istyami, A. N., Elizabeth, L., Prakoso, T., Subagjo, & Soerawidjaja, T. H. (2021). The effect of Ca/Mg/Zn mixing ratio on the research octane number of bio-gasoline during basic soap pyrolysis. Heliyon, 7(11), e08314. https://doi.org/10.1016/j.heliyon.2021.e08314

Rahmi, I. W., Nurhikma, E., Badia, E., & Ifaya, M. (2017). Formulasi sabun pembersih kewanitaan (feminime hygiene) dari ekstrak kulit buah durian (Durio zibethinus Murray). Jurnal Mandala Pharmacon Indonesia, 3(2), 80–89. https://doi.org/10.35311/jmpi.v3i02.8

Richardson, R., & Collins, A. E. (2023). Infectious disease risk communication and engagement using puppetry and related approaches for improving handwashing with soap in an informal settlement of Nairobi. International Journal of Disaster Risk Reduction, 84, 103477. https://doi.org/10.1016/j.ijdrr.2022.103477

Ross, I., Bick, S., Ayieko, P., Dreibelbis, R., Wolf, J., Freeman, M. C., Allen, E., Brauer, M., & Cumming, O. (2023). Effectiveness of handwashing with soap for preventing acute respiratory infections in low-income and middle-income countries: a systematic review and meta-analysis. The Lancet, 401(10389), 1681–1690. https://doi.org/10.1016/S0140-6736(23)00021-1

Sá-Leite, A. R., Simpson, I. C., Fraga, I., & Comesaña, M. (2024). A standardized approach to measuring gender transparency in languages. Acta Psychologica, 246, 104236. https://doi.org/10.1016/j.actpsy.2024.104236

Schlichting, M. L., Wong, J., Masen, M., De Pauw, S., Van Hoecke, H., & Kadiric, A. (2024). Experimental study of frictional behaviour of powdered soaps for wire drawing. Tribology International, 195, 109651. https://doi.org/10.1016/j.triboint.2024.109651

Sexton, J. D., Picton, J. L., Herdt, B., Black, E., & Reynolds, K. A. (2024). Removal, kill, and transfer of bacteria from hands by antibacterial or nonantibacterial soaps after handling raw poultry. Journal of Food Protection, 87(6), 100272. https://doi.org/10.1016/j.jfp.2024.100272

Shah, D. S., Jha, D. K., Gurram, S., & Amin, P. D. (2022). Process parameter optimization for the preparation of soap granules by Comil. Cleaner Materials, 4, 100093. https://doi.org/10.1016/j.clema.2022.100093

Sica, V. P., Friberg, M. A., Teufel, A. G., Streicher-Scott, J. L., Hu, P., Sauer, U. G., Krivos, K. L., Price, J. M., Baker, T. R., Abbinante-Nissen, J. M., & Woeller, K. E. (2022). Safety assessment scheme for menstrual cups and application for the evaluation of a menstrual cup comprised of medical grade silicone. EBioMedicine, 86, 104339. https://doi.org/10.1016/j.ebiom.2022.104339

Todd, E. C. D., Michaels, B. S., Holah, J., Smith, D., Greig, J. D., & Bartleson, C. A. (2010). Outbreaks where food workers have been implicated in the spread of foodborne disease. Part 10. Alcohol-based antiseptics for hand disinfection and a comparison of their effectiveness with soaps. Journal of Food Protection, 73(11), 2128–2140. https://doi.org/10.4315/0362-028X-73.11.2128

VanderGiessen, M., Tallon, A. K., Damico, B., Lahondère, C., & Vinauger, C. (2023). Soap application alters mosquito-host interactions. IScience, 26, 106667. https://doi.org/10.1016/j.isci.2023.106667

Yogesh, H., Pooja, G., Kumar, M. M., Sangeetha, M., Kumaran, R., Balakumaran, M. D., Mythily, R., Tamizhdurai, P., & Mangesh, V. L. (2024). Isolation of carminic acid from essential oil, its characterization and applications towards replacing toxic colourants used in soaps. South African Journal of Chemical Engineering, 47, 28–38. https://doi.org/10.1016/j.sajce.2023.10.007

Downloads

Published

2026-08-31

How to Cite

Astuti, S. C. D., Oiii, N., Porouw, H. S., Purkon, D. B., & Haerussana, A. N. E. M. (2026). Effectiveness of Loranthus sp. Liquid Soap in Improving Skin Moisture among Pregnant Women with Gestational Diabetes Mellitus. MEDICA (International Medical Scientific Journal), 8(8), 816–831. https://doi.org/10.53770/medica.v8i8.1266