Effect of Tamarillo Juice Consumption on Hemoglobin Levels and Wound Healing in Patients with Diabetic Foot Ulcers
https://doi.org/10.53770/medica.v8i6.975
Keywords
Diabetic Food Ulcers Hemoglobin Tamarillo Wound HealingAbstract
Anemia is a common but often overlooked complication in patients with diabetic foot ulcers (DFUs), and reduced hemoglobin levels are associated with delayed wound healing and adverse clinical outcomes. This study aimed to evaluate the effect of tamarillo (Solanum betaceum) juice consumption on hemoglobin levels and wound healing in patients with diabetic foot ulcers in Poso Regency, Indonesia. A quasi-experimental study with a pretest–posttest control group design was conducted involving 38 patients with diabetic foot ulcers receiving treatment at independent nursing practices. Participants were assigned to either an intervention group, which consumed 250 mL of tamarillo juice daily for four weeks in addition to standard wound care, or a control group that received standard wound care alone. Hemoglobin levels were measured using a calibrated hematology analyzer, while wound healing was assessed using the Bates-Jensen Wound Assessment Tool before and after the intervention. Data were analyzed using paired and independent statistical tests according to data distribution, with a significance level of p < 0.05. After four weeks, the intervention group demonstrated significantly higher hemoglobin levels than the control group (11.52 vs. 10.95 g/dL; p = 0.019) and significantly better wound healing outcomes, as indicated by lower Bates-Jensen scores (22.11 vs. 32.32; p < 0.001). These findings suggest that tamarillo juice may serve as a beneficial adjunctive nutritional intervention for improving hemoglobin levels and promoting wound healing in patients with diabetic foot ulcers. However, given the quasi-experimental design and relatively small sample size, further large-scale randomized controlled trials are warranted to confirm these findings and establish their clinical applicability.
Downloads
References
Aditya, C., Bukke, S. P. N., Anitha, K., Meeraraje, P., Goruntla, N., Yadesa, T. M., & Onohuean, H. (2025). A comprehensive review on diabetic foot ulcer addressing vascular insufficiency, impaired immune response, and delayed wound healing mechanisms. Frontiers in Pharmacology, 16, 1622055. https://doi.org/10.3389/fphar.2025.1622055
Anticona Coello, H. O., Revilla Alva, J., Diaz Delgado, B., Fernández Jeri, A. B., Muñoz Astecker, L. D., Cruzalegui Fernández, R. J., Lozano-Isla, F., & Auquiñivin Silva, E. A. (2026). Bioactive Compounds, Technological Processing, and Functional Applications of Solanum betaceum: A Systematic Review (2020–2025). Applied Sciences, 16(2), 880. https://doi.org/10.3390/app16020880
Arief, H., & Widodo, M. A. (2018). Peranan Stres Oksidatif pada Proses Penyembuhan Luka. Jurnal Ilmiah Kedokteran Wijaya Kusuma, 5(2), 22. https://doi.org/10.30742/jikw.v5i2.338
Armstrong, D. G., Tan, T.-W., Boulton, A. J. M., & Bus, S. A. (2023). Diabetic foot ulcers. JAMA, 330(1), 62–75. https://doi.org/10.1001/jama.2023.10578.
Burgess, J. L., Wyant, W. A., Abujamra, B. A., Kirsner, R. S., & Jozic, I. (2021). Diabetic Wound-Healing Science. 57(10), 1072. https://doi: 10.3390/medicina57101072.
Diep, T., Pook, C., & Yoo, M. (2020). Phenolic and anthocyanin compounds and antioxidant activity of Tamarillo (Solanum betaceum Cav.). Antioxidants, 9(2), 169. https://doi.org/10.3390/antiox9020169
Diep, T. T., Rush, E. C., & Yoo, M. J. Y. (2022). Tamarillo (Solanum betaceum Cav.): A Review of Physicochemical and Bioactive Properties and Potential Applications. Food Reviews International, 38(7), 1343–1367. https://doi.org/10.1080/87559129.2020.1804931
Faradist, A., Reny, I., & Wungu, C. D. K. (2024). The Efficacy And Benefits of Extract Solanum betaceum as A Herbal Medicine : A Literature Review. International Journal of Research Publications (IJRP), 142(1), 91–98. https://doi.org/10.47119/10.47119/IJRP1001421220246041
Frykberg R, Andersen C, Chadwick P, Haser P, Janssen S, Lee A, Niezgoda J, Serena T, Stang D, Agarwal A, Cole W, Dissemond J, Kirby J, Lantis J, Lavery L, Martinez JL, Wild T. Use of Topical Oxygen Therapy in Wound Healing. Journal Wound Care. 32(Suppl. 8b), S1–S32.. https://doi: 10.12968/jowc.2023.32.Sup8b.S1.
Guo, Y., Niu, W., Jiao, H., Li, Y., Xu, C., Zhou, X., & Wang, J. (2025). Crosstalk between oxidative stress and inflammatory pathways: Natural therapeutic approaches for diabetic wound healing. World Journal of. 16(11), 111400 https://doi.org/10.4239/wjd.v16.i11.111400
International Diabetes Federation. (2025). IDF Diabetes Atlas (11th ed.). https://diabetesatlas.org/
Kumar, R., Singh, S. K., Agrawal, N. K., Kumar, U., Kumar, S., C, S., & Bishnoi, A. (2023). The Prevalence of Anemia in Hospitalized Patients With Diabetic Foot Ulcer (DFU) and the Relationship Between the Severity of Anemia and the Severity of DFU. Cureus. 15(7), e41922. https://doi.org/10.7759/cureus.41922
Lee, S. H., Kim, S. H., Kim, K. B., Kim, H. S., & Lee, Y. K. (2024). Factors Influencing Wound Healing in Diabetic Foot Patients. Medicina (Lithuania), 60(5), 723. https://doi.org/10.3390/medicina60050723
Lin, S.-S., Chen, C.-R., Xu, W.-C., Fu, J., Xu, J.-Q., & Liang, Z.-H. (2025). Association between anemia and the risk of diabetic foot ulcer: A meta-analysis. World Journal of Diabetes, 16(6), 105155. https://doi.org/10.4239/wjd.v16.i6.105155
Machado, A. M. R., Teodoro, A. J., Mariutti, L. R. B., & Fonseca, J. C. N. da. (2024). Tamarillo (Solanum betaceum Cav.) wastes and by-products: Bioactive composition and health benefits. Heliyon, 10(18), e37600. https://doi.org/10.1016/j.heliyon.2024.e37600
Muliarta, M., Tirtayasa, K., Prabawa, P. Y., & Wiryadana, K. A. (2020). Tamarillo consumption associated with increased acetylcholinesterase activity and improved oxidative stress markers in farmers exposed to daily pesticide-related activities in baturiti, Bali, Indonesia. Open Access Macedonian Journal of Medical Sciences, 8(E), 244–250. https://doi.org/10.3889/oamjms.2020.3265
Nandhini, M., Jayaraj, R., Lavanya, R., Lathika, M., Megavarthini, K., & Shanmugapandiyan. (2024). A review: the therapeutic power of natural extracts in wound recovery. Future Journal of Pharmaceuticals and Health Sciences, 4(4), 94-101. https://doi.org/10.26452/fjphs.v4i4.686
Rito, M., Marques, J., da Costa, R. M. F., Correia, S., Lopes, T., Martin, D., Canhoto, J. M. P. L., Batista de Carvalho, L. A. E., & Marques, M. P. M. (2023). Antioxidant Potential of Tamarillo Fruits—Chemical and Infrared Spectroscopy Analysis. Antioxidants, 12(2), 536. https://doi.org/10.3390/antiox12020536
Salsabila, S. A., & Sudiono, J. (2022). Anti-Inflamatory Effect of Tamarillo Peel Extract on IL-6 Rat Post Carrageenin Induction. Jurnal Biomedika Dan Kesehatan, 5(2), 75–81. https://doi.org/10.18051/JBiomedKes.2022.v5.75-81
Simbolon, J. L., & Sitompul, E. S. (2021). Tamarillo Juice (Solanum betaceum Cav) as An Alternative to Increase Hemoglobin Levels for Pregnant Women with Anemia. Babali Nursing Research, 2(3), 106–119. https://doi.org/10.37363/bnr.2021.2355
Wang, S., & Zhu, F. (2019). Tamarillo (Solanum betaceum): Chemical composition, biological properties, and product innovation. Trends in Food Science & Technology. 95, 45–58. https://doi.org/10.1016/j.tifs.2019.11.004
Zhang, Y., Liu, H., Yang, Y., & Feng, C. (2024). Incidence and risk factors for amputation in Chinese patients with diabetic foot ulcers : a systematic review and meta-analysis. Frontiers in Endocrinology. 15, 1405301. https://doi.org/10.3389/fendo.2024.1405301
Zulkefli, N., Nur, C., Che, M., Sayuti, N. H., Kamarudin, A. A., Saad, N., Hamezah, H. S., Bunawan, H., & Baharum, S. N. (2023). Flavonoids as Potential Wound-Healing Molecules: Emphasis on Pathways Perspective. International Journal of Molecular Sciences, 24(5), 4607. https://doi.org/10.3390/ijms2405460
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 MEDICA (International Medical Scientific Journal)

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.




