The Relationship Between Premature Rupture of Membranes (PROM) and Leukocyte Levels in Newborns
DOI:
https://doi.org/10.53770/medica.v7i1.484Keywords:
Premature Rupture of Membranes , Leukocyte Levels, NewbornsAbstract
Premature Rupture of Membranes (PROM) remains a global concern in obstetrics due to its potential to cause complications such as infections that increase maternal and neonatal morbidity and mortality. PROM occurs in approximately 10–15% of pregnancies worldwide and 8–10% in Indonesia, often before 37 weeks of gestation, contributing significantly to preterm births and neonatal deaths. Risk factors for PROM include maternal age, parity, infection, and other pregnancy-related conditions. Infection resulting from PROM can be identified through leukocyte count in newborns, with leukocytosis indicating the presence of infection. This study aimed to examine the relationship between PROM and leukocyte levels in newborns at RSUD Drs. Jacobus Luna, M.Si, Bengkayang Regency, using a descriptive-analytic design with a cross-sectional approach and total sampling of 88 respondents. Results showed that among 36 newborns with elevated leukocyte levels, 28 cases (77.8%) were born from PROM pregnancies, whereas only 8 cases (22.2%) were non-PROM. Among 52 cases with normal leukocyte levels, only 11 newborns (21.2%) had PROM, while 41 (78.8%) did not. These findings indicate that newborns from PROM pregnancies tend to have higher leukocyte counts. Statistical analysis using Chi-square showed a significant relationship between PROM and leukocyte levels, with a p-value of 0.000 (< 0.05). In conclusion, PROM is a notable risk factor for increased leukocyte counts in neonates, underscoring the importance of early detection and management of PROM to reduce the risk of neonatal infection and its associated complications.
References
Alam, M. M., Saleem, A. F., Shaikh, A. S., Munir, O., & Qadir, M. (2014). Neonatal Sepsis Following Prolonged Rupture Of Membranes In A Tertiary Care Hospital In Karachi, Pakistan. Journal of Infection in Developing Countries, 8(1), 67–73. https://doi.org/10.3855/jidc.3136
Ambarkasi, W. (2017). Identifikasi Ibu Bersalin Yang Mengalami Ketuban Pecah Dini (KPD) Di Rumah Sakit Hati Mulia Kota Kendari Tahun 2016. Skripsi. Poltekkes Kemenkes Kendari.
Boskabadi, H., & Zakerihamidi, M. (2018). Evaluation of Maternal Risk Factors, Delivery, and Neonatal Outcomes of Premature Rupture of Membrane: A Systematic Review Study. Journal of Pediatrics Review, 7(2), 77–88. https://doi.org/10.32598/jpr.7.2.77
BPS Provinsi Kalimantan Barat. (2023). Analisis Tematik Kependudukan Provinsi Kalimatan Barat (Fertilitas Remaja, Kematian Maternal, dan Imigrasi). Pontianak: BPS Provinsi Kalimantan Barat.
Guo, X., Wang, Y., & Yu, H. (2023). Relationship Between Placental Pathology And Neonatal Outcomes. Frontiers in Pediatrics. https://doi.org/10.3389/fped.2023.1201991
Hincu, M. A., Zonda, G. I., Vicoveanu, P., Harabor, V., Harabor, A., Carauleanu, A., ... & Paduraru, L. (2024). Investigating the Association between Serum and Hematological Biomarkers and Neonatal Sepsis in Newborns with Premature Rupture of Membranes: A Retrospective Study. Children, 11(1), 124. https://doi.org/10.3390/children11010124
Linehan, L. A., Walsh, J., Morris, A., Kenny, L., O’Donoghue, K., Dempsey, E., & Russell, N. (2016). Neonatal and maternal outcomes following midtrimester preterm premature rupture of the membranes: a retrospective cohort study. BMC pregnancy and childbirth, 16, 1-7. https://doi.org/10.1186/s12884-016-0813-3
Maharrani, T., & Nugrahini, E. Y. (2020). Hubungan Usia, Paritas Dengan Ketuban Pecah Dini Di Puskesmas Jagir Surabaya. Jurnal Penelitian Kesehatan Suara Forikes, 8(2), 102-108.
Maraj, H., & Kumari, S. (2021). No clarity on the definition of parity: A survey accessing interpretation of the word parity amongst obstetricians and midwives and a literature review. European Journal of Obstetrics & Gynecology and Reproductive Biology, 263, 15-19. https://doi.org/10.1016/j.ejogrb.2021.05.042
Mellisa, S. (2021). Faktor Risiko Ketuban Pecah Dini. Jurnal Medika Harapan, 03(1), 402–406.
Puspitasari, I., Tristanti, I., & Safitri, A. (2023). Faktor-Faktor Yang Mempengaruhi Kejadian Ketuban Pecah Dini Pada Ibu Bersalin Di Ruang Ponek RSU Kumala Siwi Kudus. Jurnal Ilmu Keperawatan Dan Kebidanan, 14(1).
Ridha, A. (2014). Hubungan Jumlah Leukosit Dengan Kadar C- Reaktif Protein Pada Bayi Baru Lahir dengan Indikasi Ketuban Pecah Dini di Rumah Sakit Muhammadiyah Gresik. Diploma thesis, Universitas Muhammadiyah Surabaya.
Setyatama, I. P. (2023). The effect of age, parity, and pregnancy distance on low-birth-weight babies. In Improving Health for Better Future Life: Strengthening from Basic Science to Clinical Research (pp. 214-219). CRC Press.
Shinjo, A., Otsuki, K., Sawada, M., Ota, H., Tokunaka, M., Oba, T., ... & Okai, T. (2012). Retrospective cohort study: a comparison of two different management strategies in patients with preterm premature rupture of membranes. Archives of gynecology and obstetrics, 286, 337-345. https://doi.org/10.1007/s00404-012-2271-0
Subono, R. (2022). Laporan Kegiatan Maternal Dan Perinatal Di Ruangan Kebidanan RSUD Drs. Jacobus Luna, M.Si Kabupaten Bengkayang. Bengkayang: RSUD Drs. Jacobus Luna, M.Si Kabupaten Bengkayang.
Suwarna, N. O., Yuniati, T., Cahyadi, A. I., Achmad, T. H., & Agustian, D. (2022). Faktor Risiko Kejadian Sepsis Neonatorum Awitan Dini di Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung. Sari Pediatri, 24(2), 99-105. https://doi.org/10.14238/sp24.2.2022.99-105
Syarwani, T. I., Tendean, H. M. M., & Wantania, J. J. E. (2020). Gambaran Kejadian Ketuban Pecah Dini (KPD) di RSUP Prof. Dr. R.D. Kandou Manado Tahun 2018. Medical Scope Journal, 1(2), 24–29. https://doi.org/10.35790/msj.1.2.2020.27462
Tsuda, S., Shinagawa, T., Tsumura, K., So, K., Yamasaki, F., Kawaguchi, A., ... & Yokoyama, M. (2022). Estimated time to emergence of secondary intra-amniotic infection or inflammation since the onset of the preterm premature rupture of membranes. Taiwanese Journal of Obstetrics and Gynecology, 61(4), 634-640. https://doi.org/10.1016/j.tjog.2022.01.002
Wahyuni, R. (2020). Faktor penyebab terjadinya ketuban pecah dini pada ibu bersalin di rumah sakit umum daerah sumbawa besar. Jurnal Kesehatan dan Sains, 3(2), 26-33. Retrieved from http://jurnal.lppmstikesghs.ac.id/index.php/jks/article/view/34
WHO. (2023). Preterm Birth. WHO. Retrieved from: https://www.who.int/news-room/fact-sheets/detail/preterm-birth
Zakirah, S. C., Eyanoer, P. C., Chairul, ), Azali, N., & Wiweko, B. (2020). Premature Rupture of Membrane Outcome Determinants in Reproductive Age Women. Journal of Maternal and Child Health, 5(4), 376–386.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 MEDICA (International Medical Scientific Journal)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
